You need to keep them busy, so bring some toys that they like. They might get bored or tired, so prepared some small snack that will need a long time, like a big pack m&ms.

More tips: Also when bringing babies on board, bring a baby carrier. Most if not all strollers need to be checked before boarding. Having a carrier makes it easier when you're walking across the airport either to another gate or baggage claim and it'll give you more flexibility to move/walk around.

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These tips are indeed helpful. Thanks for those. Flying with children is really very challenging. You need to keep them busy with something and should have them some snacks to eat. If you have a baby carrier then it may help you to move but make sure you can handle it well.

Yes you are right. You have to bring some stuff like toys, candy and most importantly you have to bring with you a water to keep then hydrated. 

is it better to give them drowse than no drowse medicines while traveling? or just drowse med for naughty ones. =p

First, Limit their sugar intake.

Second, pack a surprise pack- pack some surprises in your carry-on and give them one every 2 hours games/pictures, small puzzles, child magazines, kids books on your destinations,let them pick some things they'd want to ......

and dont give kids sweet foods in the evening

Other place than home is always not good for the health of the children. Try to take very good foods and take special precations for kids in other matters.

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Make sure to keep your kids occupied especially during a long flight. The last thing you need is your children feeling restless and disturbing other people in the flight.